Methylene Blue

Methylene blue (also known as methylthioninium chloride) is a synthetic chemical substance with a number of different uses. Methylene blue is used as a nootropic (cognition-enhancing) agent, as well as a bacteriologic stain.

methylene-blueIn light of recent studies, it was found that Methylene Blue has nootropic effects. The nootropic properties of Methylene Blue are expressed in:

  • improving learning and memory retention
  • increasing level of energy and reducing levels of fatigue
  • enhancing mitochondrial bioenergetics

Moreover, Methylene Blue is a powerful antioxidant and, easily penetrating the blood-brain barrier, enhances mitochondrial function and protects the neuronal cells.

It is believed that Methylene Blue is involved in redox reactions that take place in the mitochondria, thereby improving the energetic status of neurons.

Methylene Blue improves the functional state of the brain and contributes to:

  • improved efficiency of the mitochondria, which in turn generate the energy, required for performing the basic functions of the body’s cells
  • prevention of cognitive impairment, caused by mitochondrial dysfunction or anticholinergic drugs

In a new study, American scientists found that a single dose of Methylene Blue increases the response of the brain regions that are responsible for short-term memory and attention. It also increases memory retrieval by about 7%.

Of course, this study is a cause for further study of Methylene Blue and evaluation of its role in healthy aging, as well as its positive effect on brain function and memory.

In medicine, Methylene Blue is used as an antidote to cyanide and carbon monoxide poisoning. Due to the fact that it has a mild antibacterial activity, Methylene blue oral is used to treat urinary tract infections, as well as certain blood diseases.

In the first half of 2016, the FDA approved Methylene Blue in injection (ProvayBlue) as a drug for the treatment of methemoglobinemia (abnormal amount of methemoglobin). In the USA, Methylene Blue in injection is a controlled drug, and is available in the pharmacies with prescription only.

The research of the American scientists has shown that Methylene Blue may be effective in the treatment of progeria (a progressive genetic disorder that causes a child’s body to age fast).

Methylene blue is a dye, which may be used instead of the indigo carmine for a variety of procedures, for example, urologic evaluations or endoscopic evaluation of lesions.

There are reports that Methylene Blue may be effective in the treatment of Alzheimer’s disease. It is assumed that Methylene blue inhibits the tau protein, which breaks the structure and activity of the neuron.

Studies on the efficacy of Methylene Blue in the treatment of patients, suffering from Alzheimer’s disease, are continuing. Scientists will also have to find out how Methylene Blue may affect the emotional state of the person and control his mood.

The safe dose of Methylene Blue is considered a dose of 1 to 4 mg of the nootropic per 1 kg of body weight per day. However, many users prefer to use a lower dose of Methylene Blue (about 90 mcg).

At the same time, according to some researchers, namely high doses of Methylene Blue contribute to the fact that the brain starts consuming more oxygen, thus improving memory retention.

On the other hand, as shown by users’ reviews, Methylene Blue application in high doses promotes side effects. The daily dose of Methylene Blue should be selected individually, depending on tolerability.

Keep in mind that low doses (less than 2 mg of Methylene Blue/kg) are usually well tolerated and cause no adverse reactions in users.

Today, Methylene blue is available to users in powder and in solution. On the Internet, you may buy Methylene blue at the price of 7 to $ 65 per package. Price for Methylene blue usually depends on the size and number of packages ordered.

If you need to buy Methylene blue, you may purchase it online at Sigma-Aldrich Corporation. This corporation has been specializing in the production of fine chemical substances for a long time to enable science that improves the quality of life.

Despite the positive properties of Methylene Blue, it has not been approved as a dietary supplement in many countries. Now, the main area of its application are the research or purposes other than human consumption.

Scientists still have to conduct detailed studies of Methylene Blue and reveal all its useful properties.